In oral cancer diagnostics, the limited availability of annotated datasets frequently constrains the performance of diagnostic models, particularly due to the variability and insufficiency of training data. To address these challenges, this study proposed a novel approach to enhance diagnostic accuracy by synthesizing realistic oral cancer lesions using an inpainting technique with a fine-tuned diffusion model. We compiled a comprehensive dataset from multiple sources, featuring a variety of oral cancer images. Our method generated synthetic lesions that exhibit a high degree of visual fidelity to actual lesions, thereby significantly enhancing the performance of diagnostic algorithms. The results show that our classification model achieved a diagnostic accuracy of 0.97 in differentiating between cancerous and non-cancerous tissues, while our detection model accurately identified lesion locations with 0.85 accuracy. This method validates the potential for synthetic image generation in medical diagnostics and paves the way for further research into extending these methods to other types of cancer diagnostics.

The labor-intensive nature of medical data annotation presents a significant challenge for respiratory disease diagnosis, resulting in a scarcity of high-quality labeled datasets in resource-constrained settings. Moreover, patient privacy concerns complicate the direct sharing of local medical data across institutions, and existing centralized data-driven approaches, which rely on amounts of available data, often compromise data privacy. This study proposes a federated few-shot learning framework with privacy-preserving mechanisms to address the issues of limited labeled data and privacy protection in diagnosing respiratory diseases. In particular, a meta-stochastic gradient descent algorithm is proposed to mitigate the overfitting problem that arises from insufficient data when employing traditional gradient descent methods for neural network training. Furthermore, to ensure data privacy against gradient leakage, differential privacy noise from a standard Gaussian distribution is integrated into the gradients during the training of private models with local data, thereby preventing the reconstruction of medical images. Given the impracticality of centralizing respiratory disease data dispersed across various medical institutions, a weighted average algorithm is employed to aggregate local diagnostic models from different clients, enhancing the adaptability of a model across diverse scenarios. Experimental results show that the proposed method yields compelling results with the implementation of differential privacy, while effectively diagnosing respiratory diseases using data from different structures, categories, and distributions.

This study introduces Reverse-Speech-Finder (RSF), a groundbreaking neural network backtracking architecture designed to enhance Alzheimer's Disease (AD) diagnosis through speech analysis. Leveraging the power of pre-trained large language models, RSF identifies and utilizes the most probable AD-specific speech markers, addressing both the scarcity of real AD speech samples and the challenge of limited interpretability in existing models. RSF's unique approach consists of three core innovations: Firstly, it exploits the observation that speech markers most probable of predicting AD, defined as the most probable speech-markers (MPMs), must have the highest probability of activating those neurons (in the neural network) with the highest probability of predicting AD, defined as the most probable neurons (MPNs). Secondly, it utilizes a speech token representation at the input layer, allowing backtracking from MPNs to identify the most probable speech-tokens (MPTs) of AD. Lastly, it develops an innovative backtracking method to track backwards from the MPNs to the input layer, identifying the MPTs and the corresponding MPMs, and ingeniously uncovering novel speech markers for AD detection. Experimental results demonstrate RSF's superiority over traditional methods such as SHAP and Integrated Gradients, achieving a 3.5% improvement in accuracy and a 3.2% boost in F1-score. By generating speech data that encapsulates novel markers, RSF not only mitigates the limitations of real data scarcity but also significantly enhances the robustness and accuracy of AD diagnostic models. These findings underscore RSF's potential as a transformative tool in speech-based AD detection, offering new insights into AD-related linguistic deficits and paving the way for more effective non-invasive early intervention strategies.

Raman spectroscopy has attracted significant attention in various biochemical detection fields, especially in the rapid identification of pathogenic bacteria. The integration of this technology with deep learning to facilitate automated bacterial Raman spectroscopy diagnosis has emerged as a key focus in recent research. However, the diagnostic performance of existing deep learning methods largely depends on a sufficient dataset, and in scenarios where there is a limited availability of Raman spectroscopy data, it is inadequate to fully optimize the numerous parameters of deep neural networks. To address these challenges, this paper proposes a data generation method utilizing deep generative models to expand the data volume and enhance the recognition accuracy of bacterial Raman spectra. Specifically, we introduce DiffRaman, a conditional latent denoising diffusion probability model for Raman spectra generation. Experimental results demonstrate that synthetic bacterial Raman spectra generated by DiffRaman can effectively emulate real experimental spectra, thereby enhancing the performance of diagnostic models, especially under conditions of limited data. Furthermore, compared to existing generative models, the proposed DiffRaman offers improvements in both generation quality and computational efficiency. Our DiffRaman approach offers a well-suited solution for automated bacteria Raman spectroscopy diagnosis in data-scarce scenarios, offering new insights into alleviating the labor of spectroscopic measurements and enhancing rare bacteria identification.

Recently, deep-learning weather forecasting models have surpassed traditional numerical models in terms of the accuracy of meteorological variables. However, there is considerable potential for improvements in precipitation forecasts, especially for heavy precipitation events. To address this deficiency, we propose Leadsee-Precip, a global deep learning model to generate precipitation from meteorological circulation fields. The model utilizes an information balance scheme to tackle the challenges of predicting heavy precipitation caused by the long-tail distribution of precipitation data. Additionally, more accurate satellite and radar-based precipitation retrievals are used as training targets. Compared to artificial intelligence global weather models, the heavy precipitation from Leadsee-Precip is more consistent with observations and shows competitive performance against global numerical weather prediction models. Leadsee-Precip can be integrated with any global circulation model to generate precipitation forecasts. But the deviations between the predicted and the ground-truth circulation fields may lead to a weakened precipitation forecast, which could potentially be mitigated by further fine-tuning based on the predicted circulation fields.

Accurate surface solar irradiance (SSI) forecasting is essential for optimizing renewable energy systems, particularly in the context of long-term energy planning on a global scale. This paper presents a pioneering approach to solar radiation forecasting that leverages recent advancements in numerical weather prediction (NWP) and data-driven machine learning weather models. These advances facilitate long, stable rollouts and enable large ensemble forecasts, enhancing the reliability of predictions. Our flexible model utilizes variables forecast by these NWP and AI weather models to estimate 6-hourly SSI at global scale. Developed using NVIDIA Modulus, our model represents the first adaptive global framework capable of providing long-term SSI forecasts. Furthermore, it can be fine-tuned using satellite data, which significantly enhances its performance in the fine-tuned regions, while maintaining accuracy elsewhere. The improved accuracy of these forecasts has substantial implications for the integration of solar energy into power grids, enabling more efficient energy management and contributing to the global transition to renewable energy sources. Figure 1: 6-hourly averaged SSI forecasts over a 48-hour period.

Prediction models inform important clinical decisions, aiding in diagnosis, prognosis, and treatment planning. The predictive performance of these models is typically assessed through discrimination and calibration. However, changes in the distribution of the data impact model performance. In health-care, a typical change is a shift in case-mix: for example, for cardiovascular risk management, a general practitioner sees a different mix of patients than a specialist in a tertiary hospital. This work introduces a novel framework that differentiates the effects of case-mix shifts on discrimination and calibration based on the causal direction of the prediction task. When prediction is in the causal direction (often the case for prognosis predictions), calibration remains stable under case-mix shifts, while discrimination does not. Conversely, when predicting in the anti-causal direction (often with diagnosis predictions), discrimination remains stable, but calibration does not. A simulation study and empirical validation using cardiovascular disease prediction models demonstrate the implications of this framework. This framework provides critical insights for evaluating and deploying prediction models across different clinical settings, emphasizing the importance of understanding the causal structure of the prediction task.

Breast cancer is not preventable because of its unknown causes. However, its early diagnosis increases patients' recovery chances. Machine learning (ML) can be utilized to improve treatment outcomes in healthcare operations while diminishing costs and time. In this research, we suggest two novel feature selection (FS) methods based upon an imperialist competitive algorithm (ICA) and a bat algorithm (BA) and their combination with ML algorithms. This study aims to enhance diagnostic models' efficiency and present a comprehensive analysis to help clinical physicians make much more precise and reliable decisions than before. K-nearest neighbors, support vector machine, decision tree, Naive Bayes, AdaBoost, linear discriminant analysis, random forest, logistic regression, and artificial neural network are some of the methods employed. This paper applied a distinctive integration of evaluation measures and ML algorithms using the wrapper feature selection based on ICA (WFSIC) and BA (WFSB) separately. We compared two proposed approaches for the performance of the classifiers. Also, we compared our best diagnostic model with previous works reported in the literature survey. Experimentations were performed on the Wisconsin diagnostic breast cancer dataset. Results reveal that the proposed framework that uses the BA with an accuracy of 99.12\%, surpasses the framework using the ICA and most previous works. Additionally, the RF classifier in the approach of FS based on BA emerges as the best model and outperforms others regarding its criteria. Besides, the results illustrate the role of our techniques in reducing the dataset dimensions up to 90\% and increasing the performance of diagnostic models by over 99\%. Moreover, the result demonstrates that there are more critical features than the optimum dataset obtained by proposed FS approaches that have been selected by most ML models.

Data-driven deep learning models have shown great capabilities to assist radiologists in breast ultrasound (US) diagnoses. However, their effectiveness is limited by the long-tail distribution of training data, which leads to inaccuracies in rare cases. In this study, we address a long-standing challenge of improving the diagnostic model performance on rare cases using long-tailed data. Specifically, we introduce a pipeline, TAILOR, that builds a knowledge-driven generative model to produce tailored synthetic data. The generative model, using 3,749 lesions as source data, can generate millions of breast-US images, especially for error-prone rare cases. The generated data can be further used to build a diagnostic model for accurate and interpretable diagnoses. In the prospective external evaluation, our diagnostic model outperforms the average performance of nine radiologists by 33.5% in specificity with the same sensitivity, improving their performance by providing predictions with an interpretable decision-making process. Moreover, on ductal carcinoma in situ (DCIS), our diagnostic model outperforms all radiologists by a large margin, with only 34 DCIS lesions in the source data. We believe that TAILOR can potentially be extended to various diseases and imaging modalities. 1 Main Breast cancer has become the most common cancer among women globally [1-3], and early detection These authors carried out this work as interns at Yizhun Medical AI Co., Ltd. The distribution of pathological subtypes is long-tailed in our training set which has 1,387 biopsy-confirmed lesions. In benign lesions, the two most frequent subtypes together account for 49.7% of the lesions, with the remaining 13 subtypes comprising 50.3%. In malignant lesions, the most frequent subtype accounts for 81.8% of the lesions, while the remaining 15 subtypes comprise only 18.2%. In breast cancer detection, ultrasound (US) is an essential imaging method widely adopted worldwide for its safety and low cost [5-7].

Diagnostic tests which can detect pre-clinical or sub-clinical infection, are one of the most powerful tools in our armoury of weapons to control infectious diseases. Considerable effort has been therefore paid to improving diagnostic testing for human, plant and animal diseases, including strategies for targeting the use of diagnostic tests towards individuals who are more likely to be infected. Here, we follow other recent proposals to further refine this concept, by using machine learning to assess the situational risk under which a diagnostic test is applied to augment its interpretation . We develop this to predict the occurrence of breakdowns of cattle herds due to bovine tuberculosis, exploiting the availability of exceptionally detailed testing records. We show that, without compromising test specificity, test sensitivity can be improved so that the proportion of infected herds detected by the skin test, improves by over 16 percentage points. While many risk factors are associated with increased risk of becoming infected, of note are several factors which suggest that, in some herds there is a higher risk of infection going undetected, including effects that are correlated to the veterinary practice conducting the test, and number of livestock moved off the herd.